Clinicopathological features of malignant lipomatous tumours: A 10-year single centre experience from northern Pretoria

ABSTRACT

¹Mlotshwa N,
²Mhlongo LN ,
³Khaba MC ,
⁴Kgokong N

¹Sefako Makgatho Health Sciences University, School of Medicine, Pretoria, South Africa
²Sefako Makgatho Health Sciences University, School of Medicine, Pretoria, South Africa
³Sefako Makgatho Health Sciences University, School of Medicine, Pretoria, South Africa
⁴Department of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Service, South Africa

Background

Liposarcomas (LPS) are rare, fast-growing, soft tissue sarcomas (STSs) of adipocyte cells. They are more prevalent STS subtypes, with five major subtypes, primarily affecting the elderly and showing a slight male predilection. The aetiopathogenesis of LPS has been linked to radiation treatment and familial cancer syndromes. These tumours pose significant health challenges to affected individuals, growing to large sizes and showing a high risk of metastasis, impacting quality of life. The study aimed to explore the clinicopathological characteristics of liposarcoma to outline the disease burden and characterise the clinicopathological characteristics that are critical in patient management.
Methods:

Method

This retrospective and descriptive study analysed data requested from the National Health Laboratory Services Corporate Data Warehouse (CDW). The study included all LPS cases diagnosed in Northern Pretoria from 1 January 2014 to 31 December 2023. Demographic and clinicopathological data were collected

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PRESENTING AUTHOR

Mr. Njabulo Mlotshwa, Honours in Anatomical Pathology

Student, Sefako Makgatho health Sciences University

EDUCATION
Sefako Makgatho Health Science University
2025- present
MSc
Anatomical Pathology

Sefako Makgatho Health Science University
2024
BSc. Hons (Cum Laude)
Anatomical Pathology

University of Pretoria
2021
BSc
Medical Science

High school: Daliwonga Secondary School
2015
Senior Certificate
(English First Additional Lang, IsiZulu Home Lang,
Mathematics, Life Sciences, Physical Science, Geography)

WORK EXPERIENCE
Jan 2022- April 2022
Field Worker
- My role as a field agent was to collect information from households
using in-person interviews, the clerical and administrative work of the
information gathered, setting and meeting missions and duties on a
daily basis, reviewing progress status with superiors and co-workers.

Honours Tutor
2025-Present
- Teaching students data analysis
- Presenting lectures on histology stains and techniques
- Presenting lectures on research biases and how to overcome them
- Lab work assistance: explaining the microtome principle, sectioning, and preparing slides
- Mini-dissertation and Protocol writing and structure
- Setting test papers and marking

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