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ABSTRACT

  • 1Keetse OM,
  • 2Moshawa MC ,
  • 3Thobakgale NM ,
  • 4Mhlongo LN
  • 1Department of Anatomical Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria
  • 2Department of Anatomical Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria
  • 3Department of Anatomical Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria
  • 4Department of Anatomical Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria

Background

Gastrointestinal lymphoma is the most common type of extranodal lymphoma, accounting for 30–40% of all extranodal lymphomas. Most of the GI lymphomas are of B-cell lineage and many occur in the background of HIV. There is considerable variation in terms of incidence of histological subtypes and sites of involvement, across different parts of the world. As a result, there is a need for a comprehensive examination of gastrointestinal lymphoma in a region with high HIV burden. This study aims to determine the prevalence and describe the histological subtypes of the GIT lymphomas in our centre.

Method

Retrospective descriptive study analyzed cases diagnosed with gastrointestinal lymphoma using STATA software. Data was retrieved from Central Data Warehouse of National Health Laboratory Service.

Result

35 gastrointestinal lymphoma cases were enrolled in this study. The overall mean age was 41,3 (3-80 years), with male predominance (71.4%). The mean age for females was 38.1 (17-67) and 42.6 (3-80) for males. The most common anatomical site was the anus (45.7%) and the least affected was the oesophagus at 2.8%. The most common histological diagnosis was plasmablastic lymphoma (48.6%) and the least diagnosed was Burkitt lymphoma at 8.6%. HIV status was confirmed positive in 45.7% of the cases.

Conclusion

Gastrointestinal lymphoma was most common in men. The female patients were younger. The most frequent site was the anus and the commonly diagnosed was plasmablastic lymphoma.
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PRESENTING AUTHOR

Dr. Olivia Keetse, MBCHB

Registrar, Sefako Makgatho Health Sciences University

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